What is a cell anyway?
The Immortal Life of Henrietta Lacks discusses the importance of HeLa cells in providing a way for scientists to better understand how the human body works, and develop new technologies and treatments for many deadly diseases… but what is a cell anyway?
Cells are the building blocks that all living things are made of.
Every thing that humans (and all other living things) do is made possible by our cells. They allow us to grow, heal, move, communicate, get nutrients from what we eat and fight off diseases.
Despite being tiny (usually microscopic!), cells are filled with even smaller parts that all allow it to carry out these important jobs.
Our body is made of over 37 trillion cells!
But not all of those cells look alike, for example the neuron cells in our spinal column stretch up to one metre, and look very different to the tightly packed epithelial cells that line the insides of our organs. Despite looking very different, the basic machinery inside most cells is pretty similar!
Welcome to #CellCity
Cells are filled with lots of different little compartments, called organelles, and they all work together to allow the cell to do its job in our body. We could think of this like the city or town where we live: everyone has to do their job to make it work.
Illustrations by Ellie Shipman, with support from Helen Zenner (St. Johnston Lab, Gurdon Institute)
Click here to learn more!
Inside a Cell
There is a lot going on in each cell. In this video we burst open a cell and have a closer look at some of the compartments inside, including the mitochondria.
The team in the Gurdon Institute Ma Lab studies how damaged DNA in the mitochondria can lead to human disease. This knowledge can help us to better understand how to treat them.
Click here to find out more about the incredible work taking place in the Ma Lab.
Video created and narrated by Anna Klucnika (Ma Lab, Gurdon Institute)
So now that we better understand what cells are and what goes on inside them, it’s time to explore what makes the HeLa cells so special…
What advances have HeLa cells enabled?
In 1951, HeLa cells became the first in vitro immortal cell line - cells that can grow and divide endlessly when looked after by scientists in the lab. This made them ideal for use in biomedical research, and since the 50s, they have underpinned a huge number of scientific discoveries in human health and disease.
Below are just some of the scientific advancements and discoveries that were made possible by the HeLa cell line.
Animation created by Amy Foreman & Tara Srinivas (Brand Lab, Gurdon Institute). Click here to find out more about the research taking place in the Brand Lab.
Why are HeLa cells so important?
Henrietta’s cells were the first cells grown in culture that were ‘immortal’ - they could divide forever if given the correct environment. This was a massive scientific breakthrough. Now scientists all across the world could perform studies and experiments on the exact same cells, leading to some huge landmark discoveries, including cloning, gene mapping and in vitro fertilisation.
How to look after HeLa cells in the lab?
Cell cultures have revolutionised how scientists study living things in the lab. This video explains how these cells are looked after, and why HeLa cells (and other immortal cell lines) provide such a valuable tool to explore human health and disease.
To find out more about how cells are cultured in the lab, click here.
Video by the Gurdon Institute PE Team, with support from Oriol LLora Batlle, Anna Klucnika and Roopali Pradhan (Gurdon Institute)
About the Gurdon Institute
Wellcome / Cancer Research UK Gurdon Institute
Named after the co-founder, Nobel Laureate Sir John Gurdon, the Wellcome Trust /Cancer Research UK Gurdon Institute is a world-leading centre for fundamental research into the biology of development and how normal growth and maintenance go wrong in diseases such as cancer.
The scientists investigate development and disease at the level of molecules, cells and tissues in research areas such as lung development and the repair of DNA, utilising a range of organisms including yeast, worms, fruit flies, frogs, chickens, mice and human cells.
The fundamental research of the Gurdon Institute generates knowledge for more applied discoveries, such as new medicines, and spin-out companies formed by Institute members have been highly successful in developing new drugs that are currently in clinical use to treat cancers.